The 1st Carpathian Biophotonics Meeting (CBM2025) is delighted to host the Opening Plenary Talk from Prof. Masaru Ishii, University of Osaka, Japan
Prof. Masaru Ishii
Department of Immunology and Cell Biology,
Graduate School of Medicine (Dean) / Graduate School of Frontier Biosciences
The University of Osaka, Japan
mishii[at]icb.med.osaka-u.ac.jp
Short CV:
Prof. Masaru Ishii currently serves as Professor of Immunology and Cell Biology at University of Osaka in Japan, and also as Dean of the Graduate School of Medicine at the same university. He has built a remarkable career in immunology and cell biology, being acknowledged by the scientific community as one of the key leaders of this field. Prof. Ishii has received numerous prestigious awards, including the JSPS Prize and the JSI Prize, reflecting his impactful contributions to immunology, osteoimmunology, and biomedical imaging. He has published extensively, with over 180 scientific papers to date, including high-impact articles in Nature, Nature Medcine, and Nature Communications, among others top-tier journals. Prof. Ishii also holds leadership roles in several national and international scientific societies, underscoring his influence in the biomedical research community. Among key contributions in the field of biophotonics, Prof. Masaru Ishii has been at the forefront of using real-time, intravital two-photon and nonlinear microscopy to observe cellular behavior in live animals. His landmark works have transformed how researchers study immune responses and bone biology dynamically and in situ. Overall, Prof. Masaru Ishii has brought remarkable contributions to understanding disease mechanisms such as rheumatoid arthritis, cancer metastasis, and bone disorders, showing the clinical potential of biophotonics in diagnosis and therapy
Opening Plenary Talk Abstract:
Spatiotemporal heterogeneity of in vivo immune systems – an intravital optical imaging study
During the last decade, intravital multiphoton microscopy has launched a new trend in the field of life sciences. By using this advanced imaging technique, we have established a new system for visualizing in situ behavior of a diversity of living cells within intact tissues and organs. Among them, we first succeeded in visualizing the various dynamic phenomena within bones, where various kinds of immune and hematopoietic cells are produced and functioning although poorly analyzed by conventional methodology such as histological analyses with decalcified sections. By utilizing intravital microscopy, we have so far identified in vivo modes of migration and function of different cell types. In addition, intravital imaging has enabled us to grasp in situ behaviors of local immune response in vivo, especially focusing on lung and liver, leading to the identification of the native systems and their responsible cell types. In this talk, I will present the latest advances in imaging-based life sciences for ‘seeing the unseen phenomenon’, especially focusing on spatiotemporal heterogeneity/variability of immune systems in vivo.
Ishii, Masaru, et al. “Sphingosine-1-phosphate mobilizes osteoclast precursors and regulates bone homeostasis.” Nature 458.7237 (2009): 524-528.
Maeda, Hiroki, et al. “Real-time intravital imaging of pH variation associated with osteoclast activity.” Nature chemical biology 12.8 (2016): 579-585.
Furuya, Masayuki, et al. “Direct cell–cell contact between mature osteoblasts and osteoclasts dynamically controls their functions in vivo.” Nature communications 9.1 (2018): 300.
Morimoto, Akito, et al. “SLPI is a critical mediator that controls PTH-induced bone formation.” Nature Communications 12.1 (2021): 2136.
Miyamoto, Yu, et al., “Periportal macrophages protect against commensal-driven liver inflammation.” Nature 629 (2024): 901-909.